Learning effective protein representations is critical in a variety of tasks in biology such as predicting protein functions. Recent sequence representation learning methods based on Protein Language Models (PLMs) excel in sequence-based tasks, but their direct adaptation to tasks involving protein structures remains a challenge. In contrast, structure-based methods leverage 3D structural information with graph neural networks and geometric pre-training methods show potential in function prediction tasks, but still suffers from the limited number of available structures. To bridge this gap, our study undertakes a comprehensive exploration of joint protein representation learning by integrating a state-of-the-art PLM (ESM-2) with distinct structure encoders (GVP, GearNet, CDConv). We introduce three representation fusion strategies and explore different pre-training techniques. Our method achieves significant improvements over existing sequence- and structure-based methods, setting new state-of-the-art for function annotation. This study underscores several important design choices for fusing protein sequence and structure information. Our implementation is available at https://github.com/DeepGraphLearning/ESM-GearNet.

Social media sites are becoming a key factor in politics. These platforms are easy to manipulate for the purpose of distorting information space to confuse and distract voters. Past works to identify disruptive patterns are mostly focused on analyzing the content of tweets. In this study, we jointly embed the information from both user posted content as well as a user's follower network, to detect groups of densely connected users in an unsupervised fashion. We then investigate these dense sub-blocks of users to flag anomalous behavior. In our experiments, we study the tweets related to the upcoming 2019 Canadian Elections, and observe a set of densely-connected users engaging in local politics in different provinces, and exhibiting troll-like behavior.

Person-Job Fit is the process of matching the right talent for the right job by identifying talent competencies that are required for the job. While many qualitative efforts have been made in related fields, it still lacks of quantitative ways of measuring talent competencies as well as the job's talent requirements. To this end, in this paper, we propose a novel end-to-end data-driven model based on Convolutional Neural Network (CNN), namely Person-Job Fit Neural Network (PJFNN), for matching a talent qualification to the requirements of a job. To be specific, PJFNN is a bipartite neural network which can effectively learn the joint representation of Person-Job fitness from historical job applications. In particular, due to the design of a hierarchical representation structure, PJFNN can not only estimate whether a candidate fits a job, but also identify which specific requirement items in the job posting are satisfied by the candidate by measuring the distances between corresponding latent representations. Finally, the extensive experiments on a large-scale real-world dataset clearly validate the performance of PJFNN in terms of Person-Job Fit prediction. Also, we provide effective data visualization to show some job and talent benchmark insights obtained by PJFNN.